Jaraden

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Wired for Threat: Clinical Features of Nervous System Dysregulation in 80 Children.Pediatric neurology2018

Abstract

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BACKGROUND: The negative effect of perceived stress on health has become a cultural epidemic. Despite many health implications, the clinical impact of stress on the nervous system is not well understood. This case series describes the symptom profiles of 80 children with nervous system dysregulation attributed to maladaptive neuroendocrine responses to stress.METHODS: We reviewed of 80 children with nervous system dysregulation identified from a single, tertiary care pediatric neurology clinic. Included patients were between five and 17 years of age, with unexplained medical symptoms lasting three months or longer affecting at least four of six neurological domains: (1) somatization, (2) executive function, (3) autonomic function, (4) digestion, (5) sleep, and (6) emotional regulation. Medical symptoms, diagnoses, and detailed social histories were collected.RESULTS: Of 80 children, 57 were female (71%), 57 were Caucasian (71%), with median age of 14 years. Symptoms had a mean duration of 32 months, and included: 100% somatic symptoms, 100% emotional dysregulation, 92.5% disrupted sleep, 82.5% autonomic dysregulation, 75% executive dysfunction, and 66% digestive problems. Overall, 94% reported chronic or traumatic stressors; adverse childhood experiences were present in 65%.CONCLUSIONS: Perceived stress impacts many functions of the neuroendocrine system through experience-dependent plasticity, resulting in a constellation of symptoms and functional impairments we describe as nervous system dysregulation. The pathophysiology of these symptoms involves dysregulation of subcortical, hormonal, and autonomic circuits, which remain largely untested. Recognition and understanding of maladaptive neurophysiology in stress-related symptoms has important implications for diagnosis, treatment, and advances in health research.

View details for PubMedID 30343833

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Founded in 1973, Jarden Plastic Solutions, formerly known as Unimark Plastics, is a full-service company that specializes in precision injection molding. The company supplies plastic and manufacturing solutions. It serves clients in the health care, precision consumer and closure markets. Jarden Plastic Solutions also offers program management and engineering services. The company provides boxing, bagging and wrapping equipment, as well as catheters and needles. In addition, it offers tool design, prototyping and mold flow analysis solutions. The company manages more than five manufacturing plants in the United States. It operates a thermoforming and extrusion division that was established in 1975. Jarden Plastic Solutions is a division of Jarden Corporation, which is a publicly traded company.

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